Trumps VIP therapy: receiving a drug treatment that has not yet been approved

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 Trumps VIP therapy: receiving a drug treatment that has not yet been approved


According to NBC financial channel (CNBC), Dr. Scott Gottlieb, former director of the U.S. Food and Drug Administration (FDA), said in an interview on October 2 local time that he believed that the White House must have carefully considered all treatments before deciding to use regenerons experimental new coronavirus antibody cocktail therapy for trump The plan.

Second from left: Scott Gottlieb

Since trump was diagnosed, the White House sent trump to Walter Reed National Military Medical Center out of great care..

Trump arrives at Walter Reed National Military Medical Center

Not everyone in the medical community, however, agrees with Gottliebs decision to experiment with trump. Some have expressed concern about providing such special treatment to the president because the drug has not yet been approved by federal regulators; others have pointed out that the product has limited data available.

As one doctor commented on Twitter: without data, VIP drugs dont mean better drugs.

The White House did not immediately respond to CNBCs comment on the decision to inject trump with antibody drugs.

Regeneron confirmed that an 8 g dose of regn-cov2 was provided to trump. The drug is still in the experimental phase and has not yet been authorized for emergency use by the FDA, but it provides a sympathetic response to requests for use.

According to CNBC, after talking to Dr. George yancopoulos, chief scientific officer of regeneron, a limited number of patients received the drug on this basis.

A novel coronavirus pneumonia (REGN-COV2) is a combination of two monoclonal antibodies (REGN10933 and REGN10987) designed specifically to block new crown viruses that can cause new crown pneumonia. It simulates the human bodys response to foreign invaders. The goal is to enhance the immune systems defense capabilities, rather than waiting for human biological processes to complete its work.

These antibodies come from novel coronavirus pneumonia mice that have been genetically modified and have antibodies identified from the new crown pneumonia rehabilitation. Two effective virus neutralizing antibodies formed regn-cov2. According to regeneron, the antibody cocktail has no competitive binding with the key receptor binding domain of the spike protein (s protein) of the new coronavirus, reducing the ability of the mutant virus to evade treatment, thus protecting the mutated s protein in the human body. Preclinical studies have shown that regn-cov2 can reduce viral load and associated damage in non-human primates.

On September 29th, novel coronavirus pneumonia, Regeneron said on its website that their REGN-COV2 treatment improved symptoms and reduced viral load in patients with mild to moderate new crown pneumonia. This is based on the data of the first 275 trial patients. At the time, the company said it planned to discuss early results quickly with regulators, including the FDA.

Among the first 275 Regeneron participants aged 44 years, 49% were male and 51% were female; about 56% were Hispanic and 13% were African American; 64% had one or more potential risk factors for Yan Zhongxins pneumonia, including obesity (over 40%).

Novel coronavirus pneumonia is also the only drug that is being developed by Regeneron. Lilly and GlaxoSmithKline are also testing monoclonal antibodies. Experts believe this is a promising new treatment for pneumonia.

In a memorandum provided by the White House on Friday, Trumps doctor Sean Conley said: as a precaution, the president received a regeneron antibody cocktail. Conley also wrote that trump was still tired, but in a good mood.

Trump has had a fever since Friday morning, according to a person familiar with the matter.

In addition, Trumps aides began to feel unwell and seemingly exhausted on Wednesday, but believed it was related to his busy campaign schedule, according to the news agency.

The New York Times also reported that trump seemed listless at Thursdays fundraising event, and he was said to have fallen asleep on his plane after the rally on Wednesday.

Gottlieb said that if novel coronavirus pneumonia is to be treated early, Trump probably thought of remdesivir, the first of his kind. (Reed). Because it has been authorized by the FDA for emergency use, but it is only applicable to critically ill inpatients.

I thought they were going to use radcivir because there was a lot of data on this drug, Gottlieb said He added that he was optimistic about regenerons treatment, but it may be too early.

However, Gottlieb refutes the claim that Trumps treatment with regeneron should cause caution. Novel coronavirus pneumonia is diagnosed by almost all other Americans, and is monitored by medical professionals, hoping that the symptoms will not increase.

For the president of the United States, if you have a treatment available, I think you will provide it, especially if you understand the safety of these products and you believe it is safe and will not worsen his condition, Gottlieb said

However, some doctors are skeptical about the decision to treat trump with antibody drugs.

Its bad science and bad medical ethics to give unproven things to powerful people, Dr. Vinay Prasad, an assistant professor of medicine and practicing hematology oncologist at the University of California, San Francisco, wrote on twitter

Dr. VIN Gupta, a chest specialist in Seattle, added: Id like to say that Ive never heard of a patient, especially an important figure like the president, receiving an experimental antibody cocktail therapy. He also called on the White House to provide more information.

In addition to regenerons antibody cocktail therapy, trump also took zinc, vitamin D and famotidine (histamine H)_ 2 receptor blockers).

The novel coronavirus pneumonia is currently speculative, although researchers are studying whether famotidine is beneficial to patients with new crown pneumonia, Gottlieb said. He added: studies have shown that vitamin D supplementation is beneficial if you are deficient in vitamin D, but its better to supplement it before you get sick. I dont think theres any problem with these drugs or the potential for harm, I just dont know if theyll provide a therapeutic effect in this situation.

In addition, novel coronavirus pneumonia risk is likely to be a focus of Trumps CNN (CNN).

Trump already has several risk factors and is a high-risk group. The details are as follows:

Age: novel coronavirus pneumonia (CDC) data show that the risk of hospitalization is 5 times higher than that of 18-29 year old young people, and that of the new age of crown pneumonia is 90 times higher than that of the age group of 65-74.

Obesity: according to his medical report in April, trump weighed 244 pounds and was 6 feet 3 inches tall. This brings his BMI to 30.5. Theoretically, novel coronavirus pneumonia increases the risk of hospitalization by two times if it is mildly obese, according to CDC data.

Male: trump is male. Novel coronavirus pneumonia is more common among men than women, according to authoritative health agencies.

Others: I dont know if trump has any other diseases that might put him in high-risk groups. According to his recent physical examination, his blood pressure is only slightly elevated. There is no evidence that he has cancer, kidney disease, diabetes or other diseases that put people at higher risk.

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