Timothy brown, the worlds first AIDS patient to be cured, has died of cancer recurrence, the International AIDS Association said in a statement on September 30.
We are very grateful to Timothy and his doctor gro Schutter for opening the door for scientists to explore the concept that aids can be cured, said Adiba kamaluzaman, President of the International AIDS Association
According to media reports, Brown has been fighting a relapse of leukemia for months and received hospice care at his home in Palm Springs, California.
Born in 1966, American Brown is recognized as the worlds first cured AIDS patient. He was diagnosed with AIDS in 1995 while living in Berlin, Germany, and was diagnosed with acute myeloid leukemia in 2006. Brown received radiation therapy and stem cell transplantation in Berlin in 2007, after which aids and leukemia disappeared.
Brown stopped antiretroviral treatment for HIV shortly after transplanting stem cells and found no detectable HIV in his body. In other words, he was cured. Browns experience shows that aids can one day be cured. This has promoted a series of efforts to study the treatment of AIDS.
More than ten years after Brown was cured, Adam castilejo, known as the London patient, has not detected active HIV in a long observation period after receiving stem cell transplantation, and is widely considered to be the second AIDS patient to be cured.
One thing the two patients had in common was a rare mutation in the CCR5 receptor of the stem cell donor, which made the body resistant to HIV and prevented it from entering the host cell. CCR5 is a major entry point for HIV to attack human body. The researchers believe that the replacement of immune cells with cells without CCR5 receptors through stem cell transplantation may be the reason why HIV does not rebound after stopping treatment.
Experts say that although Browns and castilejos treatment is not a feasible strategy to cure AIDS on a large scale, it represents the direction of finding a cure for AIDS.
Source: responsible editor of Xinhua News Agency: Qiao JunJing_ NBJ11279