Is oral collagen IQ tax

 Is oral collagen IQ tax

This article will answer these questions one by one.

Todays article is from Stella of clinical medicine, Cambridge University. Please rest assured~

What is collagen

On the market, oral collagen is basically extracted from animals and marine organisms.

However, as an old aunt who has learned biology and medicine courses, I have always been full of doubts about the theory of oral collagen to keep young forever:

In those days, before the outbreak, I sat in the classroom and learned that any kind of protein, no matter from chicken, beef or fish, could not escape the digestion and decomposition of protease in the small intestine during digestion.

After passing through the small intestine, it has been broken into small single amino acid structures, or dipeptides (short chains of two amino acids holding hands) and tripeptides (short chains of three amino acids holding hands).

We need a picture explanation here

For example, our gut is like a factory that splits parts. No matter whats coming in, Volkswagen, Mercedes Benz and Audi wont give you back the basic elements of iron, copper and titanium, and they will tear them up into small parts that mom cant recognize.

But I dont give up. After a search, I was shocked. The collagen I ate was really useful.

Can I go to the skin

First of all, conclusion:

After digestion and absorption, oral collagen can reach the skin and cartilage tissue.

Lets first take a look at what collagen we take orally is.

This spiral structure is composed of three different amino acids in a group of short chain repeated.

Because of this unique ingredient, the spiral structure of collagen is very stable. Thats why collagen supports the soft tissue and keeps our skin from sagging.

It doesnt matter if you cant understand these amino acids. Knock on the blackboard and draw the key points:

Glycine, proline and hydroxyproline are important components of collagen.

As mentioned before, the dipeptide (pro Hyp) can be directly absorbed and utilized by the small intestine, which is why hydrolyzed collagen will be promoted, because the absorption effect is better than eating natural collagen directly.

In one study, the researchers fed mice the same dipeptide (pro Hyp) as the hydrolyzed collagen on the market, which is the molecular structure of collagen that can be directly absorbed by the digestive tract.

In the experiment, these hydrolyzed collagen are inserted with special markers, so that we can track their whereabouts.

That is to say, after these mice are fed with the labeled hydrolyzed collagen, they will be irradiated, and we can know where the collagen is absorbed.

At the same time, the researchers also found that these markers exist in many collagen related cells, such as the fibroblasts that make collagen.

That is to say, the molecular structure of the absorbed collagen will indeed come to our skin and joints, which are already in great need of collagen.

Another similar study also found that although the collagen components taken will be utilized by various tissue structures, they will stay in the skin for the longest time, up to 14 days.

Thats another side of why collagen makes skin good.

Sisters, see here super excited have not!

First, dont be excited. I want to find a hammer for collagen to make skin better. Ive looked up a lot of literature, and I have some tips!

In one study, dozens of women aged 40 to 65 were given collagen extracted from fish or pigs once a day.

After four to 12 weeks of continuous use, the researchers analyzed their skin changes and found these benefits:

01 oral collagen improves moisture in the skin

02 oral collagen effectively increases the density of collagen in the dermis

In this study, researchers regularly used ultrasound to monitor changes in collagen in womens skin during the experiment.

As can be seen from the chart (red represents the oral collagen group, blue represents the control group with nothing to eat), as early as 4 weeks after the experiment, the collagen content in the skin of the women who took oral collagen was higher than that of the control group with nothing to eat.

03 oral collagen can effectively reduce the fragmentation of collagen structure

As we mentioned earlier, all proteins have a normal structure to maintain their biological functions.

In the process of skin aging, not only the content of collagen becomes less, but also the quality of a lot of collagen in the skin becomes worse. The structure of collagen will be damaged for various reasons, resulting in protein breakage.

In the long run, the support ability of collagen for skin will continue to decline.

Compared with the control group and the women taking collagen, after 12 weeks, the collagen structure in the skin of the women taking collagen was larger, indicating that the degree of structure fragmentation was smaller, which was 31.2% less in the control group.

Obviously, there were more gaps in the group of eating nothing (right column of the two pictures), while the group of taking collagen (left column of the two pictures) had dense and better collagen network.

04 oral collagen increases the synthesis of collagen in human skin

In dozens of women who took collagen, it was also found that long-term oral collagen can accelerate the synthesis of collagen in the skin.

Oral collagen increased the content of glycosaminoglycan in human skin

Let me first explain what glycosaminoglycan is.

The following four pictures show the distribution of glycosaminoglycan in the skin of the experimental subjects.

Apparently, women who ate collagen had more glycosaminoglycan in their skin.

This also explains why oral collagen can enhance the moisture content of the skin.

There are other clinical trials that have shown that taking collagen can improve the skin in other ways. For example, oral collagen can effectively reduce wrinkles and fine lines.

In one study, 114 women, 45 to 65, were divided into two groups. One group was given oral short peptide collagen, the best collagen component to absorb, while the other group was the control group.

After 8 weeks of daily use, the amount of wrinkles around the eyes of women in the experimental group decreased significantly.

The picture below is from the original paper. On the left is the appearance of two participants before taking collagen, and on the right is the appearance after taking collagen for 8 weeks.

And its amazing that this change can be long-term, because the reduction in wrinkles can still be observed four weeks after the experiment stopped.

06 oral collagen can also improve skin elasticity

After 12 weeks, the degree of skin deformation in the experimental group was significantly improved than that in the control group.


Collagen is good for others

In addition to skin, collagen can also improve many other parts of the body.

Oral collagen can increase the toughness of nails, making them not easy to break.

80% of the participants said that after oral administration of collagen, their nail appearance improved significantly.

Oral collagen can improve the condition of hair.

Collagen can improve injured joints.

In a study, Penn State University recruited 147 athletes who had participated in sports competitions and divided them into experimental group and control group. The experimental group was given 10 g of collagen hydrolysate once a day.

After 24 weeks, the joint pain of the athletes in the experimental group was significantly reduced.

One study involved 31 men between the ages of 18 and 60 who had 20 to 30 percent burns on their bodies.

Studies have shown that collagen can accelerate the healing of skin wounds and reduce the length of hospital stay.

Although I have listed a lot of scientific research supporting the efficacy of collagen today, you should understand that in these studies, women participating in the experiment take a lot of collagen every day.

Individual differences between people are also very large. Taking the same amount of collagen may work for other little sisters, but it doesnt work for them.

There are a lot of advertisements boasting about collagen on the Internet, and there are also a lot of rumors against collagen.

So, we should also treat collagen correctly and accept our maturity in body and mind happily.

1.Asserin,J.,Lati,E.,Shioya,T.,&Prawitt,J.(2015).Theeffectoforalcollagenpeptiesupplementationonskinmoistureantheermalcollag ennetwork:eviencefromanexvivomoelanranomize ,placebou2010con trolleclinicaltrials.Journalofcosmeticermatology ,14(4),291-301.

2.AvilaRoru00edguez,M.I.,RoriguezBarroso,L.G.,&Su00e1nchez,M.L.(2018). Collagen:Areviewonitssourcesanpotentialcosmeticapplications.Journalofcosmeticermatology ,17(1),20-26.

3.Miyab,K.B.,Alipoor,E.,Vagharoost,R.,Isfeevajani,M.S.,Yaseri,M.,jafarian,K.,&Hosseinzaeh-Attar,M.J.(2020).Theeffectofahyrolyzecollagen-basesupplementonwounhealinginpatient swithburn:Aranomizeouble-blinpilotclinicaltrial.Burns ,46(1),156-163.

4.Clark,K.L.,Sebastianelli,W.,Flechsenhar,K.R.,Aukermann,.F.,Meza,F.,Millar,R.L.,...&Albert,A.(2008).24-Weekstuyontheuseofcollagenhyrolysateasaietarysupplementinathleteswithactivity- relatejointpain.Currentmeicalresearchanopinion ,24(5),1485-1496.

5.Kawaguchi,T.,Nanbu,P.N.,&Kurokawa,M.(2012).istributionofprolylhyroxyprolineanitsmetabolitesafterora laministrationinrats.BiologicalanPharmaceuticalBulletin ,35(3),422-427.

6.Proksch,E.,Schunck,M.,Zague,V.,Segger,.,egwert,J.,&Oesser,S.(2014).Oralintakeofspecificbioactivecollagenpeptiesreucesskinwrinklesanincreases ermalmatrixsynthesis.Skinpharmacologyanphysiology ,27(3),113-119.

(function(){( window.slotbydup=window .slotbydup||[]).push({id:u6056789,container:ssp_ 6056789, async:true });})();7.Watanabe-Kamiyama,M.,Shimizu,M.,Kamiyama,S.,Taguchi,Y.,Sone,H.,Morimatsu,F.,...&Komai,M.(2010).Absorptionaneffectivenessoforallyaministerelowmolecularweightcoll agenhyrolysateinrats.Journalofagriculturalanfoochemistry ,58(2),835-841.8.Yagoa,M.,&Gans,E.(2014).Anutritionalsupplementformulatewithpepties,lipis, collagenanhyaluronicacioptimizeskeyaspectsofphysicalappearanceinnails, hairanskin.JNutrFooSci .S,5,002.

8.Yagoa,M.,&Gans,E.(2014).Anutritionalsupplementformulatewithpepties,lipis,collagenanhyaluronicacioptimizeskeyaspectsofphysicalappearanceinnails, hairanskin.JNutrFooSci .S,5,002.