Chinese team asymptomatic patients research release: detoxification period longer than symptomatic patients

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 Chinese team asymptomatic patients research release: detoxification period longer than symptomatic patients


The results showed that the immune response of asymptomatic patients was much lower than that of symptomatic patients, and the detoxification time of asymptomatic patients was longer than that of symptomatic patients. In addition, they found abnormalities in CT images of the lungs of the majority (59%) of asymptomatic infections.

Long detoxification period

Weak immune response

The results of the study, published online June 18 in the journal Nature Medicine, will provide an important reference for the study of asymptomatic patients. The corresponding authors are Huang Ailong, President of Chongqing Medical University, Chen Juan, researcher of Chongqing Medical University and Qiu Jingfu, Dean of School of public health and management of Chongqing Medical University.

The researchers compared 37 asymptomatic patients who were confirmed to be infected by nucleic acid test in Wanzhou District of Chongqing, but did not have the disease 14 days later. They found that the average detoxification cycle of these asymptomatic patients was 19 days, longer than that of the symptomatic patients, and the average detoxification cycle of the light patients was 14 days. But the researchers stressed that the duration of detoxification should not be equal to the infectivity of the virus.

The definition of detoxification period and the frequency of nucleic acid sampling will affect the change of detoxification period. More importantly, the detection of viral nucleic acid does not necessarily indicate the existence of infectious virus in the sample. Special care should be taken when evaluating the potential infectivity based on the results of nucleic acid detection. The researchers said.

Another important finding is that the level of immune factors produced by asymptomatic patients is lower than that of symptomatic patients, which indicates that their immune response is weak. The decrease of IgG and neutralizing antibody in the early stage of rehabilitation may affect the immune strategy and serological investigation.

Asymptomatic lung

CT

There are also abnormalities

But asymptomatic patients do not mean they are not ill. According to the findings of imaging, chest CT scan showed that 21 of 37 asymptomatic patients had abnormal lung images, and two thirds of them had abnormal lung images in one lung of both lungs.

The researchers also pointed out that 37 asymptomatic infections accounted for more than 20% of the 178 samples, but this proportion could not be used to accurately assess the overall size of asymptomatic patients, because these asymptomatic patients were identified from high-risk population samples, not randomly selected samples. In order to obtain the true proportion of asymptomatic infections, random screening is needed. And because some cases may be missed by nucleic acid detection, it suggests that the proportion of actual asymptomatic infection is higher.

This is the first in-depth study based on immunology for asymptomatic patients, said Eric Topol, director of the Institute of translational Sciences at Scripps Research in the US, commenting on social media

(function(){( window.slotbydup=window .slotbydup||[]).push({id:u6056789,container:ssp_ 6056789, async:true });})(); Professor Yan Xuebing, director of infection and liver disease department and leader of epidemic treatment expert group of Affiliated Hospital of Xuzhou Medical University, told the first financial reporter: the latest research results are different from the previous findings, for example, the detoxification time of asymptomatic patients is longer, but on the whole, asymptomatic patients and symptomatic patients have similar detoxification mode. According to the conclusion that the immune level of asymptomatic infected people is low, Professor Yan Xuebing thinks that this can only show that the systemic immune response of asymptomatic infection is not obvious, but it can not show that the local immune response or cellular immune response is lower than that of symptomatic infection. In theory, if you get rid of the virus after infection and you dont get infected again and you get immunity, thats the best outcome. Local immunity is the first line of defense against pathogens, which is very important for non-specific immunity of the body, he told the first financial reporter Who: new coronavirus in Beijing is closely related to European strains | who are 183 new confirmed cases in Beijing in eight days? Where have you been? Source: First Financial Editor: Han Jiapeng_ NN9841

Professor Yan Xuebing, director of infection and liver disease department and leader of epidemic treatment expert group of Affiliated Hospital of Xuzhou Medical University, told the first financial reporter: the latest research results are different from the previous findings, for example, the detoxification time of asymptomatic patients is longer, but on the whole, asymptomatic patients and symptomatic patients have similar detoxification mode.

In theory, if you get rid of the virus after infection and you dont get infected again and you get immunity, thats the best outcome. Local immunity is the first line of defense against pathogens, which is very important for non-specific immunity of the body, he told the first financial reporter