Is the five minutes test better? Expert: nucleic acid test is irreplaceable at present

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 Is the five minutes test better? Expert: nucleic acid test is irreplaceable at present


In view of the current situation and development direction of new coronavirus detection technology in various countries, China Science Daily interviewed Huang Yanyi, a professor of Peking University and deputy director of Beijing advanced innovation center for future genetic diagnosis, as well as Wang Jianbin, a researcher of Life College of Tsinghua University. A novel coronavirus laboratory test was introduced in the May 14th Science Lecture on understanding the future.

Five minute artifact is not a new invention

In the report and interview, Huang Yanyi repeatedly stressed that nucleic acid detection is still irreplaceable, this technology has been repeatedly verified and optimized for more than 20 years, and its specificity and sensitivity have been proved by time. At the same time, the speed of nucleic acid detection is not slow, and a small number of samples can produce results in 30 minutes at least.

However, since the outbreak, nucleic acid testing has been negative for several times, and it is not uncommon for the cases to turn positive finally, which makes many people begin to doubt the reliability of nucleic acid testing.

So what is the level of nucleic acid detection in China? Wang Jianbin told China Science Daily that the current nucleic acid detection methods used in various countries have some differences in the sequence location of the virus. A recent study by a South Korean scientist showed that the effectiveness of these different detection sites varied. Among them, China and the United States selected the most effective and sensitive loci.

It can be said that China and the United States are tied for the first place in nucleic acid detection technology. Wang Jianbin said, this reflects from the side that Chinese scientists are very accurate in early selection of virus detection sites, which tests the experience, ability and judgment of scientists.

The future of saliva sampling

With the rapid expansion of the epidemic, the demand for detection is also changing. When home isolation becomes normal, self sampling and self testing become very practical needs.

According to Huang Yanyi, scientists from Yale University in the United States have reported that saliva sampling is even more stable than nasopharynx swabs. Recently, Rutgers University and its subordinate testing agencies have been approved by the FDA to use saliva samples for the detection of new coronavirus. They use a pipelined automation machine that can detect 10000 samples a day. The domestic West China Hospital has also published relevant reviews.

Saliva sampling is a very encouraging new method. If it is popularized, it is expected to solve many problems we faced in the past. Wang said. But he also said with a smile, we tried to get 5 ml saliva needed for sampling, which is not easy.

DNA sequencing, not just testing

When we conceived the subject, the new coronavirus was still an unknown thing to humans. Wang Jianbin said, but after the development of SHERRY, it just caught up with the outbreak. Because the new coronavirus is an RNA virus, it can be sequenced easily, stably and quickly by sherry.

Wang Jianbin said that the technology will not be directly applied to clinical detection of new coronavirus for the time being, but it will help to answer a series of questions that have not been answered at present, such as why the symptoms of infected people are very different, the formation mechanism of asymptomatic infected people and Fuyang patients, etc.

At present, we have found that many samples may have different mutations in specific sites. Will these mutations affect the accuracy of detection in the future? Will it affect vaccine development and drug testing? Further research is needed. Huang Yanyi said.

(function() {(window. Slotbydup = window. Slotbydup| []). Push ({ID: u5811557, container: ssp_, async: true});}) ()); relevant recommendations for the White House to test the new crown artifact in 5 minutes or to be terminated? Nearly 50% missed inspection! Three new crown test boxes newly approved by the United States: to reduce standards for large-scale testing, the health and Health Commission responded to Wuhan to carry out full nucleic acid testing: conducive to accurate prevention and control. Source: responsible editor of China Science Daily: Wang ning_nb12468