Nature: pangolin may be a potential intermediate host of new coronavirus

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 Nature: pangolin may be a potential intermediate host of new coronavirus


The research was carried out by researchers from Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and technology, South China Agricultural University, Guangzhou Zoo and other institutions. Before that, relevant achievements had been released in China in February, which had attracted great attention at that time.

The results showed that the amino acid sequence similarity between a coronavirus isolated from a Malaya pangolin and a new coronavirus was up to 100%. The receptor binding region of pangolin spike protein is almost the same as that of new coronavirus, with only one non key amino acid difference. The comparative analysis of genomes showed that the new coronavirus may be derived from the recombination of pangolin coronavirus and a strain of coronavirus (tg13) in bats. The results suggest that novel coronavirus may be the potential intermediate host of new coronavirus.

Previous studies have shown that bats may be the host of the new coronavirus; the intermediate host can be said to be the second hand in the process of virus transmission from natural host to human.

The authors of the report said in February that, in general, there may be multiple intermediate hosts, in addition to pangolins, there may be other small carnivores that have played a role in the spread of the virus to humans.

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