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New coronavirus potential intermediate host or pangolin, complete scientific data to be released

category:Internet
 New coronavirus potential intermediate host or pangolin, complete scientific data to be released


According to the introduction, the research team targeted pangolin as a potential intermediate host of new type of coronavirus by analyzing more than 1000 samples of macro genome; then, through molecular biological detection, revealed that the positive rate of u03b2 - coronavirus in pangolin was 70%; further isolation and identification of the virus, typical particle structure of coronavirus was observed under the electron microscope; finally, through genome analysis of the virus It was found that the sequence similarity between the isolated strain and the current infected strain was as high as 99%.

It is worth noting that when scientists confirmed civet cat as intermediate host during SARS period, gene sequencing analysis of civet cat SARS virus showed that the homology with human SARS virus was over 99.8%. What does 99% similarity mean this time?

In an interview with surging news reporter (www.thepaper. CN), a virologist said that it is necessary to see the complete scientific data, 99% similarity, here is the comparison of the whole genome? Or a clip? Or a few clips? .

Another scholar in the field of bioinformatics also told the surging news reporter, if there is 99% similarity, there are about 200 mutations in the genome, which should be 2-3 years evolutionary distance, then theoretically there should be a closer intermediate host, but this is certainly one of the important intermediate hosts. But at the same time, he stressed that at present, there is no specific data and it is not easy to draw conclusions.

Liu Yahong, executive deputy director of Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and technology and President of South China Agricultural University, introduced the release form of the research teams results at the press conference. In view of the seriousness of the current epidemic prevention and control, we chose to release the research results to the public at the first time, hoping to contribute to the scientific prevention and control of the epidemic, and carry out the research for more scientists One step work provides reference.

Xiao Lihua concluded at the conference that the teams results show that pangolin is a potential intermediate host of the new coronavirus. The results of this study are of great significance to the prevention and control of the source of the epidemic, and also provide scientific basis for the adjustment of policies related to wildlife control.

Since the outbreak of new crown pneumonia, most of the first group of patients are related to South China Seafood City in Wuhan, which is an important clue to trace the source of the virus. Xiao Lihua also said at the conference, the current evidence shows that wild animals are the source of new coronavirus, and early cases have a history of contact with the South China seafood market in Wuhan..

According to CCTV news on January 26, on December 31, 2019, according to the requirements of China CDC, the Institute of viral diseases sent an expert group to Wuhan to participate in epidemic prevention and control, and drafted the work plan for environmental traceability in the early morning of January 1, 2020. On January 1 and January 12, experts from the Institute of Virology of China CDC went to South China Seafood City twice respectively to collect 515 environmental samples from case related merchants and related blocks, and 70 samples from wildlife trafficking shops, and then transferred them to the laboratory for testing.

According to the results released on January 26, 585 samples were collected from two batches of South China Seafood City, and the PCR results showed that 33 of them were positive for new coronavirus nucleic acid. The positive samples were distributed in 22 stalls and 1 garbage truck on the market, of which 93.9% (31 / 33) were distributed in the western area of South China seafood market.

After investigation, it is found that the seafood market in South China is a seafood market in name, but it is actually a comprehensive market. In South China seafood market, there is wildlife trade in the west area, especially in the area near the inner market of 7th and 8th streets of the west area where there are many wildlife trade shops, and the positive specimens in this area are relatively concentrated, accounting for 42.4% (14 / 33) of the total positive samples. In conclusion, it is highly suspected that the epidemic is related to wildlife trade.

Previously, on January 30, the international top medical journal Lancet published on-line research papers by Professor Shi Weifeng and others from Shandong First Medical University and the laboratory of etiology and epidemiology of new infectious diseases of Shandong University, which also mentioned these details: the first report of the epidemic was in late December 2019, when most bats in Wuhan were hibernating; in South China Seafood Market There are no bats or sold bats, but there are many non aquatic animals, including mammals.

In fact, it is impossible to obtain wild animal samples directly from the seafood market in South China. Shen Yongyi also mentioned at the conference that the South China seafood market has been disinfected for a long time, and its difficult to trace the source further. We need to do more work later to prove this communication chain. On January 1, the day after Wuhan Municipal Health and Health Commission reported that some medical institutions found that many cases of pneumonia received were related to the South China seafood market, the South China seafood market was closed, and then the environmental sanitation treatment was carried out.

Up to now, several new coronavirus traceability work has been published. On January 21, Hao Pei, a researcher at the Pasteur Institute of Chinese Academy of Sciences, and Zhong Wu, a researcher at the National Center for emergency prevention and control drug engineering technology of the Academy of military medicine, and Li Xuan, a researcher at the center for molecular plant science excellence and innovation of the Chinese Academy of Sciences, jointly published an online article in Chinese Science: Life Sciences, suggesting that the natural host of Wuhan coronavirus might also be bats. On January 23, Shi Zhenglis team from Wuhan Institute of Virology, Chinese Academy of Sciences, published on the biorxiv prepress platform. The gene sequence consistency of the new coronavirus and SARS coronavirus reached 79.5% and 96% with that of ratg13 coronavirus in Rhinolophus yunnanensis, indicating that its natural host is probably bat. The results were also officially published in the top academic journal Nature after peer review on February 3. However, although the source of the new coronavirus is bat, which is recognized by most people in the industry, the intermediate host is still a mystery. Extend reading intelligent robot Xiaobai to join in Wuhan new crown pneumonia treatment front line 5g, AI infrared temperature detector, Ministry of industry and information technology: daily production capacity of more than 10000 aaais2020 academic conference look ahead: common sense knowledge and common sense reasoning this source: surging news editor: Liao ziyao nbjs10040

Up to now, several new coronavirus traceability work has been published. On January 21, Hao Pei, a researcher at the Pasteur Institute of Chinese Academy of Sciences, and Zhong Wu, a researcher at the National Center for emergency prevention and control drug engineering technology of the Academy of military medicine, and Li Xuan, a researcher at the center for molecular plant science excellence and innovation of the Chinese Academy of Sciences, jointly published an online article in Chinese Science: Life Sciences, suggesting that the natural host of Wuhan coronavirus might also be bats.

On January 23, Shi Zhenglis team from Wuhan Institute of Virology, Chinese Academy of Sciences, published on the biorxiv prepress platform. The gene sequence consistency of the new coronavirus and SARS coronavirus reached 79.5% and 96% with that of ratg13 coronavirus in Rhinolophus yunnanensis, indicating that its natural host is probably bat. The results were also officially published in the top academic journal Nature after peer review on February 3.

However, although the source of the new coronavirus is bat, which is recognized by most people in the industry, the intermediate host is still a mystery.