In addition to the achievements of Li Lanjuans team, these five drugs may be effective for new crown pneumonia

category:Global
 In addition to the achievements of Li Lanjuans team, these five drugs may be effective for new crown pneumonia


It is reported that the above joint scientific research team has carried out super large-scale computer-aided drug screening for 8506 drugs on the market or in clinical trials for multiple target proteins of 2019 new coronavirus (including MPRO protein crystal structure provided by Rao Zihe academician team of Chinese Academy of Sciences), and achieved the first stage results within one week.

It is found that there are five drugs that may be effective for the new coronavirus in 2019, namely beclabuvir, saquinavir, bitegravir, lopinavir and dolutegravir.

The joint research team found that beclabuvir can not only bind to MPRO protein, but also may be a potential inhibitor of RNA dependent RNA polymerase nsp12 of 2019 new coronavirus; saquinavir can not only bind to MPRO protein, but also can bind to S protein of 2019 new coronavirus, and can prevent virus expansion at the same time inside and on the cell surface.

It is understood that at present, the joint research team is carrying out cytological verification of the above five antiviral drugs and promoting clinical trials of the drugs. The research results released by the joint research team will be open to biomedical research institutions through Huawei cloud and used in the research and development of antiviral drugs.

Beijing News on the afternoon of February 4, Li Lanjuan, academician of the Chinese Academy of engineering and member of the high level expert group of the National Health Care Commission, announced the latest research results on the treatment of pneumonia caused by the new coronavirus. Abidor (approved by the State Administration of drug administration as abidor, hereinafter referred to as abidor) and darunavir can effectively inhibit the disease Poison.

(function() {(window. Slotbydup = window. Slotbydup| []). Push ({ID: u5811557, container: ssp_, async: true});)) (); according to the preliminary test, in vitro cell experiments showed that: (1) under the concentration of 10-30 u03bc mol, abidol can effectively inhibit the coronavirus up to 60 times, and significantly inhibit the pathological effect of the virus on cells compared with the untreated control group. (2) Compared with the control group, the inhibition efficiency of darunavir was 280 times.

According to the preliminary test, in vitro cell experiments showed that: (1) compared with the untreated control group, abidol can effectively inhibit the coronavirus up to 60 times, and significantly inhibit the pathological effect of the virus on the cells. (2) Compared with the control group, the inhibition efficiency of darunavir was 280 times.