Hubei Daily News on February 3, Beijing time, Wuhan Institute of Virology, Chinese Academy of Sciences / biosafety research center, Wuhan Jinyintan hospital and Hubei Provincial Center for Disease Control and prevention jointly launched a new type of coronavirus identification research work with pneumonia outbreak and a possible bat origin New coronavirus) was published online in nature, a top international academic journal. The relevant research team revealed the basic biological characteristics of the coronavirus from the aspects of nucleic acid detection, serological diagnosis, virus isolation and receptor utilization, providing important clues for epidemic control and drug research and development.
The paper was submitted on January 20, 2020, received by the Journal on January 29, and finally published online on February 3. This is also the first time that nature has published research on new coronaviruses in the form of official papers. In the race against time and epidemic situation, the study provides detailed basic biological characteristics of 2019 new coronavirus in a short period of time, and reveals that bat may be the natural host of the virus. The team found that the new coronavirus can infect non sensitive cells that express human ACE2 (the receptor of SARS CoV), indicating that the new coronavirus can use the receptor of SARS CoV to invade cells. These studies laid a foundation for the follow-up epidemic prevention and drug research.
According to the Wuhan Institute of viruses, Chinese Academy of Sciences, the results of pathogen identification, isolation and judgment of possible natural hosts of viruses have been reported to the relevant departments of the state, provinces and cities in a timely manner. Zhou Peng, researcher of Wuhan Institute of Virology, Yang Xinglou, associate researcher and Wang Xianguang, doctor of Jinyintan hospital were the co authors of the paper, while Shi Zhengli, researcher of Wuhan Institute of Virology, was the corresponding author.
The reporter learned that the Wuhan Institute of Virology of the Chinese Academy of Sciences is actively carrying out antiviral drug screening, animal model establishment, vaccine research and development, etc. At present, several drugs with potential clinical application value have been screened out, and the screening results have been reported to the scientific and technological research team of the national and Hubei Provincial command for the prevention and control of new coronavirus infection pneumonia epidemic situation, for the guidance of medical treatment after comprehensive study and judgment. In terms of animal models, the establishment of mouse and non-human primate models has been basically completed, which will provide key support for subsequent research.
There are also various versions of rumors on the Internet, which more or less associate the outbreak with the leakage of laboratory virus samples from domestic scientific research institutions. Following Shi Zhenglis article in the circle of friends: 2019 new coronavirus is the punishment of nature for human uncivilized living habits. I, Shi Zhengli, guarantee my life, and have nothing to do with the laboratory. Later, according to the Wuhan Institute of Virology, Chinese Academy of Sciences, for a long time, the third and fourth level laboratories of biological safety of Wuhan Institute of Virology have carried out relevant scientific research legally and in compliance with regulations, without laboratory leakage or personnel infection. The Institute will further cooperate with the superior scientific research forces in and out of the province to provide effective scientific and technological support for the effective control of new pneumonia.