The reporter learned from the Suzhou Medical Institute of the Chinese Academy of Sciences that the researchers of this institute have recently developed a new method which can detect the concentration of microRNA with high sensitivity. Because the concentration of microRNA will be abnormal in the early stage of the occurrence and development of many cancers, the popularization of this new method is expected to help more people find and diagnose cancers as soon as possible.
Microribonucleic acid is a group of small ribonucleic acid with length of 18 to 25 nucleotides. It plays an important role in regulating cell differentiation, proliferation and death. Medical studies have shown that lung cancer, pancreatic cancer, colorectal cancer and other types of cancer cells can lead to abnormal concentrations of specific microRNAs in the human body. Compared with traditional tumor markers, detection of microRNAs can help to detect disease symptoms at very early stages of cancer development. Therefore, it is called the fingerprint for searching for early cancer.
This time, researchers used clusters of dozens of silver atoms as fluorescent signal sources to detect the concentration of microRNA. In the absence of microRNAs, the signal source emits red fluorescence. When microRNAs are present in the sample, the red fluorescence turns yellow. The higher the concentration of microribonucleic acid, the weaker the original red fluorescence and the stronger the Yellow fluorescence. Comparing the intensity of the two fluorescence, the concentration of microribonucleic acid can be accurately determined.
The new method not only can detect microRNA in blood samples, but also can be combined with imaging detection to indicate the specific location of the lesion. Compared with other similar detection methods, it has better analytical performance, convenient operation, simple conditions and more convenient application and popularization. Miao Peng, a researcher at the Suzhou Institute of Medical Technology, who was responsible for the study, said.
Relevant research results have recently been published in the international authoritative sensor Journal Sensor and Actuator B: Chemistry.
Source: Responsible Editor of Xinhua News Agency: Qiao Junjing_NBJ11279