A Chinese team reported on the 9th that they found that coagulation factor, a blood component involved in blood coagulation after human injury, has the potential to play a role in the fight against multidrug-resistant superbacteria.
A team led by scholars from Sichuan University reported in the Journal Cell Research, published by the Chinese Academy of Sciences in collaboration with the British Natural Publishing Group, that they found that coagulation factors VII, IX and X played an important role in the coagulation process and might also fight gram-negative bacteria, including Pseudomonas aeruginosa and Baumann immobilization. Bacteria and other highly drug-resistant superbacteria.
The team believes that the ability of coagulation factors to hydrolyze lipopolysaccharides in bacterial envelopes suggests that they may have the potential to resist gram-negative bacteria. The team also further explored the mechanism in the laboratory.
There is no known antimicrobial substance that works by hydrolyzing lipopolysaccharides, Song Xu said. To clarify the antimicrobial mechanism based on lipopolysaccharide hydrolysis and the antimicrobial characteristics of coagulation factors, combine the ability to produce these coagulation factors on a large scale at a lower cost, or provide new strategies with high cost-effectiveness to combat the emergent public health crisis caused by drug-resistant gram-negative bacteria.
Source: Responsible Editor of Xinhua News Agency: Qiao Junjing_NBJ11279