Japan approved the first research project to cultivate human organs in animals

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 Japan approved the first research project to cultivate human organs in animals


According to Kyodo News Agency and other media reports, a special committee of the Ministry of Arts and Science of Japan approved the above-mentioned research plan proposed by a research group of Tokyo University on the 24th. The research team did not disclose the exact timing of the project. Japanese media reported that the study would be implemented in the near future to confirm whether the related technologies could be used to form organs in animals, hoping to provide assistance for transplantation medicine in the future.

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); window. slotbydup |[]. push ({id:6374560, container: s, 300, 250, infix-display});} (); the researchers will first modify the genes of the fertilized eggs of the experimental mice to prevent their normal birth. Then human iPS cells were implanted into the fertilized eggs, and animal embryos containing human cells were cultivated as animal collecting embryos. Then they were transplanted back into the uterus of experimental mice. Researchers expect fetal mice to have pancreas formed by human iPS cells when they grow up. It is reported that Japanese researchers will also implant human iPS cells in fertilized eggs of cynomolgus monkeys and pigs, but they will not be transplanted to the uterus for the time being. They will only carry out research on iPS cells. In March this year, the Ministry of Science of the Ministry of Culture of Japan revised the relevant regulations to allow the cultivation of human organs in animals, in order to strengthen research on the use of animals to cultivate human organs for transplantation. IPS cells have similar differentiation potential to embryonic stem cells by reprogramming mature somatic cells, but the method is relatively simple and avoids the ethical issues in embryonic stem cell research, which is considered to be of great value in clinical treatment. Source: Responsible Editor of Xinhua: Liu Yuxin_NBJS7825

Researchers will first modify the genes of fertilized eggs of experimental mice so that they can not normally produce their own pancreas and other organs; then implant human iPS cells into the fertilized eggs, cultivate animal embryos containing human cells, animal collecting embryos, and then transplant them back into the uterus of experimental mice. Researchers expect fetal mice to have pancreas formed by human iPS cells when they grow up.

It is reported that Japanese researchers will also implant human iPS cells in fertilized eggs of cynomolgus monkeys and pigs, but they will not be transplanted to the uterus for the time being. They will only carry out research on iPS cells.

In March this year, the Ministry of Science of the Ministry of Culture of Japan revised the relevant regulations to allow the cultivation of human organs in animals, in order to strengthen research on the use of animals to cultivate human organs for transplantation.

IPS cells have similar differentiation potential to embryonic stem cells by reprogramming mature somatic cells, but the method is relatively simple and avoids the ethical issues in embryonic stem cell research, which is considered to be of great value in clinical treatment.