Zhejiang University School of Medicine: medicine for osteoporosis or treatment of breast cancer

category:Global
 Zhejiang University School of Medicine: medicine for osteoporosis or treatment of breast cancer


By analyzing more than 5000 cases of breast cancer, the Dong Chenfang team found that a metabolic enzyme, uridine two phosphate transferase 8 (UGT8), was abnormally active and produced a large amount of glucosinolates in basal cell like breast cancer cells, and glucosinolates activated the signaling pathways of cancer cell survival and metastasis. The effect of zoledronic acid on the treatment of tumor cells was close to the effect of direct knockout of UGT8 in mice, and both of them had a similar mechanism to regulate cell metabolism and function. Dong Chenfang told Xinhua news agency that zoledronic acid has been used to treat osteoporosis, its mechanism may be related to the inhibition of osteoclast activity, and now it is a direct inhibitor of UGT8, which inhibits the invasion and metastasis of tumor cells. As a safe marketed drug, it is expected to become a target drug for the treatment of basal like breast cancer. Source: Xinhua editor: Yang Qiang _NN6027 Dong Chenfang told Xinhua news agency that zoledronic acid has been used to treat osteoporosis, its mechanism may be related to the inhibition of osteoclast activity, and now it is a direct inhibitor of UGT8, which inhibits the invasion and metastasis of tumor cells. As a safe marketed drug, it is expected to become a target drug for the treatment of basal like breast cancer.