Zhang Fengxin, a lifelong professor of Chinese post-1980s MIT, academician of the US Academy of Sciences

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 Zhang Fengxin, a lifelong professor of Chinese post-1980s MIT, academician of the US Academy of Sciences


Professor Zhang Feng (picture source network) Zhang Feng was born in Shijiazhuang, Hebei province in 1982. When he was 11 years old, he came to Des Moines, Iowa, United States with his parents, and Zhang Feng started out here in the field of life science. In an interview with STAT, a senior news website, Zhang Feng and her mother recalled that on a late autumn evening, they were attracted by the flying deciduous leaves of the sky, and they could not help feeling the short life. They realize that life can easily disappear, and even traces of existence are hard to discern. From that night on, Zhang Feng thought of what he could do to change what he could. Influenced by his parents, Zhang Feng showed great interest in programming from an early age. One time he watched Jurassic Park in the classroom, in which researchers mixed dinosaurs with the DNA of frogs and brought extinct reptiles to reality, which made Zhang Feng understand that biology could be a programmable system. The teacher observed his unusual excitement and interest in bioengineering. Before long, the teacher helped Zhang Feng find a volunteer work in a local laboratory of gene therapy. There, Zhang Feng started from scratch and learned to use the virus to move the green fluorescent protein gene in jellyfish into human melanoma cells and let it work smoothly. At that time, his lab mentors often put forward crazy ideas, such as green fluorescent protein (GFP) that absorbs ultraviolet light, so it can be used as a sunscreen. When Zhang Feng put GFP on top of DNA, he found that GFP could really prevent DNA from being damaged by ultraviolet radiation. In the year of high school, Zhang Feng, under the guidance of his tutor, made another genetic project using the virus to win the three prize for the Intel science Genius Award (IntelScienceTalentSearch) in 2000 and a $50 thousand scholarship. After graduating from high school, Zhang Feng went to Harvard University to study chemistry and physics. Zhang Feng won third photos of the IntelScienceTalentSearch prize at the age of 16. Talking about the molecular biology that chose this major instead of what he has done, Zhang Feng believes that because of the stability of the basic principles of physics and chemistry, he wants to lay a good foundation for a solid foundation for his academic path in the future. During his undergraduate study at Harvard University, Zhang Feng entered the laboratory of Professor Zhuang Xiaowei, a famous Chinese scholar, engaged in influenza virus research and published the results in the top scientific journals of the 2004, and the technology he used was the green fluorescent protein, which was in the middle of high school. After graduating from Harvard University, Zhang Feng went to Stanford University to study postgraduate. Zhang Feng, who wanted to visit the Nobel Prize winner Zhu Diwen, went into the laboratory of the young professor of neurobiology, Karl Day Arthur Roth (KarlDeisseroth). There, they jointly invented light genetics technology, that is, using optical stimuli and light sensitive proteins from algae to control brain neuronal activity. This is considered a major achievement in the field of neuroscience, which is used by researchers all over the world to locate the neural circuits of a variety of diseases, including schizophrenia, depression, or autism. It also made them deeply carved their names in the history of brain science. The discovery of the Nobel prize After his graduation, Zhang Feng left Deisseroths laboratory as a researcher at the Massachusetts Institute of Technology and entered the two top research institutions of the Massachusetts Institute of Technologys Mcgovern Brain Research Institute (McGovernInstituteforBrainResearch) and the BroadInstituteofMITandHarvard (the Expo Research Institute) and established themselves. The laboratory. Shortly afterwards, at a meeting of the Bode Advisory Committee, a guest reported his research on an immune system in the bacterial genome called CRISPR/Cas. This strange name inspired Zhang Fengs curiosity. In the 2011, a few research teams began to use CRISPR/Cas to target precise regions of the genome, but Zhang Feng had a more ambitious goal. He realized that the system is expected to be used for accurate and rapid gene editing. As a series of new studies on CRISPR/Cas were published in the top academic journals, Zhang Feng absorbed the results of previous studies in a short period of time and improved CRISPR/Cas. In 2013, Zhang Feng published a heavy study in the journal Science: they used the CRISPR-Cas9 system for the first time in mammals and confirmed that it could build a mouse model of disease within a few weeks. In addition, the Zhang Feng team successfully completed gene editing with CRISPR-Cas9 system for the first time in human cells. Since Zhang Feng broke the window paper, many advances and applications have been made in the field of genome editing. The scientific papers covered by CRISPR increased from 90 in 2012 to 741 in 2015. Zhang Feng also used a non-profit organization called Addgene to share CRISPRs information with biologists all over the world. The potential of CRISPR to search for individual gene mutations is immeasurable, and humans are expected to be able to remove the AIDS virus in every infected cell, or to treat the classic genetic diseases, such as sickle - like erythrocyte anemia. Even scientists have been using it to overcome the possibility of cancer. In addition, it can also be applied in plant genome. This can bring new bioenergy or bring more stable crops. A rising star of Science In 2014, Zhang Feng was chosen by nature as one of the ten scientific figures of the year in 2013; in 2016, Zhang Feng, one of the next generation leaders (NextGenerationLeaders), boarded the cover of the Time, and the reason for his entry was changing the science of life with the technology of transforming life. Zhang Feng boarded the cover of Time magazine (photo source network) In 2017, the worlds well-known Alberni biomedical prize (AlbanyMedicalCenterPrizeinMedicineandBiomedicalResearch) announced the award of the 2017 award to 5 outstanding scientists who made pioneering contributions in the field of genetic editing. Zhang Feng also became the second Chinese scholar to win the prize after professor Xie Xiaoliang. Alberni biomedical prize evaluation is also known as CRISPR technology for century discovery. As one of the most famous and influential awards in the field of global biomedicine, the albernie biomedical prize is regarded as the Nobel prize vane. Zhang Feng has become one of the most popular Nobel prize winners by means of an important breakthrough in CRISPR technology. Although Zhang Feng is known as CRISPR, he thinks this is only a means of achieving his true goal. He wants to use genetics to understand and eventually cure mental illness. Half of his laboratory is concentrated in brain research. Zhang Feng said that autism, depression, schizophrenia and other serious mental illness have made real progress, which is the driving force for him to move forward. If the world does not know that you have made a breakthrough, Zhang Feng told his colleagues that in fact, you did not achieve your goal. The source of this article is Mr. Yao Liwei, editor in chief of Mr. de _NT6056. As one of the most famous and influential awards in the field of global biomedicine, the albernie biomedical prize is regarded as the Nobel prize vane. Zhang Feng has become one of the most popular Nobel prize winners by means of an important breakthrough in CRISPR technology. Although Zhang Feng is known as CRISPR, he thinks this is only a means of achieving his true goal. He wants to use genetics to understand and eventually cure mental illness. Half of his laboratory is concentrated in brain research. Zhang Feng said that autism, depression, schizophrenia and other serious mental illness have made real progress, which is the driving force for him to move forward. If the world does not know that you have made a breakthrough, Zhang Feng told his colleagues that in fact, you did not achieve your goal.