According to a cross-generational study in the Journal Nature Communications, boys who grow up with nutritious food provided by their grandparents are more likely to develop cancer and have a higher overall mortality rate than boys who are undernourished.
Denny Vagero of Stockholm University in Sweden, who led the study, pointed out that our study found that there was a clear correlation between grandparentsprovision of nutritious food to their grandchildren and their future grandchildrens growth and cancer.
This phenomenon of environmental factors affecting offspring is called transgenerational response. In this case, it is only reflected in male offspring.
Wagro and his colleagues looked at data from the Uppsala population multi-generation study, which tracked 12,000 people born in Uppsala Hospital in Sweden from 1915 to 1929 and their two generations of descendants.
The analysis categorized the family status of grandparents as wealthy and poor in their infancy. Statistics showed that grandchildren who grew up in well-fed grandparents were more likely to die of diabetes and cardiovascular disease in adulthood.
The latest analysis shows that these specific disease risks will only extend to the next generation, not to two generations. We cant reproduce their often cited findings that grandparentswell-being predicts an increased risk of diabetic mortality in their grandchildren as adults, the study authors said. However, based on 289 death reports, we do find that grandchildren are more likely to develop diabetes as adults, living in carefree grandparentsfamilies.
In addition, grandparents provide abundant food for their grandchildren from an early age, and their grandchildren are at high risk of cancer in adulthood, although the relationship between the two is not clear.
Researchers speculate that adequate nutrition may trigger a signal that is captured by male gametes, possibly through DNA methylation, an epigenetic genetic genetic regulation mechanism. The resulting changes may be passed on to the next generation.
Grandparents provide abundant food during their grandchildrens infancy, and then they almost grow into adolescence. The results of this study suggest that this is an energy-intensive developmental process that may also affect genome-wide DNA methylation patterns in boys and girls, including reproductive DNA, and small non-coding RNAs in sperm cells.
Source: Liable Editor of Netease Scientist: Qiao Junyi_NBJ11279