Is pig heart capable of being transplanted into baboon for long?

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 Is pig heart capable of being transplanted into baboon for long?


Science and technology daily, Beijing, December, 6 (reporter Zhang Mengran) British Journal of nature published a breakthrough medical achievement online on 6. A team of German scientists has developed an improved method, which has achieved long-term goals after genetically modified pig heart transplantation into baboon. This is the first method that can produce many successful results. It represents a great step forward in clinical porcine heart transplantation.

For patients with advanced heart failure, transplantation is the only long-term intervention available. However, the available organ supply can not meet the current clinical needs. Therefore, it is suggested that a genetically modified pig heart be used to help solve this shortage, and a preclinical trial has been carried out in the baboon model. However, the survival period of baboon was 57 days.

Now Bruno Richard, a scientist at the University of Munich in Germany, and his colleagues have shown that a longer lifespan can be achieved repeatedly. The team used three consecutive groups of transplant subjects (16 baboons in total) to improve the technique and successfully achieved long-term transplantation in the last group.

What scientists do is to allow the heart to be oxygenated by blood circulation (rather than static refrigeration) during transplantation, and to prevent harmful expansion of transplanted organs by lowering baboon blood pressure and using compounds known to control cell growth. The last group consisted of five baboons, four of which remained healthy for at least 90 days (the experiment ended) and the longest for 195 days.

At present, further experiments are needed to improve the data, but this method has shown great progress. The maturity of this study will greatly alleviate the shortage of organ transplantation. Sci-tech Dailys editor-in-chief circled xenotransplantation makes many people sound uncomfortable, but in fact, if animal organs can be transplanted into humans and survive effectively for a long time, although recipients may have to rely on immunosuppressants for the rest of their lives, they can still provide hope for countless desperate patients. The shortage of transplantable organs will also be greatly alleviated in the whole medical field. In this process, pig organs are the best choice for us to perform xenotransplantation. Although baboons are very similar to ours, the organs of pigs are similar to ours in biology. At the same time, human beings already know pig DNA very well, and for scientists, genetic modification is easier. Source: Wang Fengzhi_NT2541, responsible editor of Science and Technology Daily - China Science and Technology Network

At present, further experiments are needed to improve the data, but this method has shown great progress. The maturity of this study will greatly alleviate the shortage of organ transplantation.

Sci-tech Daily Editor-in-Chief Circle

Xenotransplantation makes many people sound uncomfortable, but in fact, if animal organs can be transplanted into humans and survive effectively for a long time, although recipients may have to rely on immunosuppressants for the rest of their lives, they can still provide hope for countless desperate patients. The shortage of transplantable organs will also be greatly alleviated in the whole medical field. In this process, pig organs are the best choice for us to perform xenotransplantation. Although baboons are very similar to ours, the organs of pigs are similar to ours in biology. At the same time, human beings already know pig DNA very well, and for scientists, genetic modification is easier.